| Date | Opponent | Location | Time |
|---|
| 09/04/10 | vs South Dakota Coyotes | Bright House Network Stadium - Orlando, Florida | 6:00pm ET |
| 09/11/10 | vs NC State Wolfpack | Bright House Network Stadium - Orlando, Florida | 7:30pm ET |
| 09/18/10 | at Buffalo Bulls | UB Stadium - Amherst, New York | 7:00pm ET |
| 09/25/10 | at Kansas State Wildcats | Bill Snyder Family Stadium - Manhattan, Kansas | TBD |
| 10/06/10 | vs UAB Blazers | Bright House Network Stadium - Orlando, Florida | 8:00pm ET |
| 10/13/10 | at Marshall Thundering Herd | Joan C Edwards Stadium - Huntington, West Virginia | 8:00pm ET |
| 10/23/10 | vs Rice Owls | Bright House Network Stadium - Orlando, Florida | 3:30pm ET |
| 10/30/10 | vs East Carolina Pirates | Bright House Network Stadium - Orlando, Florida | 3:30pm ET |
| 11/05/10 | at Houston Cougars | Robertson Stadium - Houston, Texas | 8:00pm ET |
| 11/13/10 | vs Southern Miss Golden Eagles | Bright House Network Stadium - Orlando, Florida | 12:00pm ET |
| 11/20/10 | at Tulane Green Wave | Louisiana Superdome - New Orleans, Louisiana | 3:30pm ET |
| 11/27/10 | at Memphis Tigers | Liberty Bowl Memorial Stadium - Memphis, Tennessee | 12:00pm ET |
